Proteomics, oxidative stress and male infertility
نویسندگان
چکیده
منابع مشابه
Oxidative stress & male infertility.
The male factor is considered a major contributory factor to infertility. Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumours, a new and important cause has been identified: oxidative stress. Oxidative stress is a result of the imbalance between reactive oxygen species (ROS) and antiox...
متن کاملPower of Proteomics in Linking Oxidative Stress and Female Infertility
Endometriosis, PCOS, and unexplained infertility are currently the most common diseases rendering large numbers of women infertile worldwide. Oxidative stress, due to its deleterious effects on proteins and nucleic acids, is postulated to be the one of the important mechanistic pathways in differential expression of proteins and in these diseases. The emerging field of proteomics has allowed id...
متن کاملA Review: Role of oxidative stress in male infertility
Recent studies have shown that reactive oxygen species (ROS) have a very important role in the intracellular signaling process in physiological conditions. On the other hand, during the recent decade it has been indicated that ROS play a role in various types of male infertility and it is due to the overproduction of ROS or decrease in the antioxidant defense system in the reproductive system a...
متن کاملOxidative stress and sperm chromatin damage in male infertility.
Researchers studying the causes of male infertility have recently focused on the role played by reactive oxygen species (ROS)—a highly reactive oxidizing agent belonging to the class of free radicals. ROS are produced by a variety of semen components, and antioxidants in the seminal fluid keep their levels in check. Small amounts of ROS help spermatozoa acquire their necessary fertilizing capab...
متن کاملRelationship amongst teratozoospermia, seminal oxidative stress and male infertility
BACKGROUND Spermatozoa morphology is an important and complex characteristic of the fertilization capacity of male germ cells. Morphological abnormalities have been observed to be accompanied by reactive oxygen species (ROS) overproduction and further damage to spermatozoa, ultimately leading to infertility. Therefore, this study aimed to examine the relationship between seminal ROS production ...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2014
ISSN: 1472-6483
DOI: 10.1016/j.rbmo.2014.02.013